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KMID : 0379520030190040303
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한국독성학회지
2003 Volume.19 No. 4 p.303 ~ p.310
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Effect of APB-01 on the Ultraviolet-Induced Photoaging and Wrinkle Formation in the Hairless Mice
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Lee Ji-Hae
Lee Byoung-Seok
Byun Bum-Sun
Kim Wan-Gi
Lee Sang-Jun
Shim Young-Chul
Kim Bae-Hwan
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Abstract
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Ultraviolet (UV) is thought to induce erythema, sun-burn, photo-toxicity, photo-allergy, photo-aging and sometimes skin tumor. To investigate the photo-protective effects of APB-01 (Amore-Pacific Beauty-01, the mixture of Jaummi-dan and Fujiflavone P10) on UV-induced skin damage, forty of SKH hairless female mice were orally administered with APB-01 or saline fifth a week, and irradiated with UV third a week for up to ten weeks. We examined the relationship between visible changes and skin damage in the dermis and epidermis. In the APB-01 treated group, a better skin and less wrinkles formation were observed when compared to the UV control group. This results demonstrated that oral administration of APB-01 seems to have photo-protective effects on UV-induced skin damage of hairless mice due to an inhibitory effect on collagen breakdown, and the model using hairless mice is very useful to investigate the efficacy of functional beauty foods.
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KEYWORD
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APB-01, Jaummi-dan, Fujiflavone P10, Ultraviolet (UV), Photoaging, Hairless mice
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